Publications

Full list on Google scholar

Neuro-Immune interactions

K Murray, KM Rude, J Sladek, C Reardon. Divergence of neuroimmune circuits activated by afferent and efferent vagal nerve stimulation in the regulation of inflammation. The Journal of Physiology 599 (7), 2075-2084. 2021

V Ramirez, S Swain, K Murray, C Reardon. Neural immune communication in the control of host-bacterial pathogen interactions in the gastrointestinal tract. Infection and immunity. Sep; 88(9): e00928-19. 2020

Ramirez VT, Sladek J, Godinez DR, Rude, K, Chicco P, Murray K, Brust-Mascher I, Gareau MG, and C. Reardon. Sensory Nociceptive Neurons Contribute to Host Protection During Enteric Infection With Citrobacter rodentium. The Journal of infectious diseases. 221 (12), 1978-1988. 2020.

Murray K, Gardner MB, Rude K, and C Reardon. Functional circuitry of neuro-immune communication in the mesenteric lymph node and spleen. Brain behavior and Immunity. 82, 214-223. 2019.

Ramirez VT, Godinez DR, Brust-Mascher I, Castillo PA, Nonnecke EB, Gardner MB, Tu D, Sladek JA, Miller EN, Lebrilla CB, Bevins CL, Gareau MG, and C. Reardon. T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium. PLOS Pathogens. 15 (4), e1007719. 2019.

Reardon C, Murray K, and Alan E Lomax. Neuroimmune Communication in Health and Disease. Physiological reviews. 2018 epub Aug. 15 2018. doi: 10.1152/physrev.00035.2017. Review. PMID: 30109819

Murray K, Reardon C. The cholinergic anti-inflammatory pathway revisited. Neurogastroenterol Motil. 2018 Mar;30(3). doi: 10.1111/nmo.13288. Review. PubMed PMID: 29468816; PubMed Central PMCID: PMC5826620.

Murray K, Godinez DR, Brust-Mascher I, Miller EN, Gareau MG, Reardon C. Neuroanatomy of the spleen: Mapping the relationship between sympathetic neurons and lymphocytes. PLoS One. 2017 Jul 28;12(7):e0182416. doi: 10.1371/journal.pone.0182416. eCollection 2017. PubMed PMID: 28753658; PubMed Central PMCID: PMC5533443.

Reardon C. Neuro-immune interactions in the cholinergic anti-inflammatory reflex. Immunol Lett. 2016 Oct;178:92-6. doi: 10.1016/j.imlet.2016.08.006. Epub 2016 Aug 16. Review. PubMed PMID: 27542331.

Reardon C, Duncan GS, Brüstle A, Brenner D, Tusche MW, Olofsson PS, Rosas-Ballina M, Tracey KJ, Mak TW. Lymphocyte-derived ACh regulates local innate but not adaptive immunity. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1410-5.
doi: 10.1073/pnas.1221655110. Epub 2013 Jan 7. Erratum in: Proc Natl Acad Sci U SA.. Olofsson, Peder [corrected to Olofsson, Peder S]. PubMed PMID: 23297238; PubMed Central PMCID: PMC3557089.

Rosas-Ballina M, Olofsson PS, Ochani M, Valdés-Ferrer SI, Levine YA, Reardon C, Tusche MW, Pavlov VA, Andersson U, Chavan S, Mak TW, Tracey KJ. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science. 2011 Oct 7;334(6052):98-101. doi: 10.1126/science.1209985. Epub 2011 Sep 15. PubMed PMID: 21921156; PubMed Central PMCID: PMC4548937.

Host pathogen interactions

Rizzuti D, Ang M, Sokollik C, Wu T, Abdullah M, Greenfield L, Fattouh R, Reardon C, Tang M, Diao J, Schindler C, Cattral M, Jones NL. Helicobacter pylori inhibits dendritic cell maturation via interleukin-10-mediated activation of the signal transducer and activator of transcription 3 pathway. J Innate Immun. 2015;7(2):199-211. doi: 10.1159/000368232. Epub 2014 Nov 20. PubMed PMID: 25412627.

McIlwain DR, Grusdat M, Pozdeev VI, Xu HC, Shinde P, Reardon C, Hao Z, Beyer M, Bergthaler A, Häussinger D, Nolan GP, Lang KS, Lang PA. T-cell STAT3 is required for the maintenance of humoral immunity to LCMV. Eur J Immunol. 2015
Feb;45(2):418-27. doi: 10.1002/eji.201445060. Epub 2014 Dec 15. PubMed PMID: 25393615; PubMed Central PMCID: PMC4383653.

Smith CJ, Emge JR, Berzins K, Lung L, Khamishon R, Shah P, Rodrigues DM, Sousa AJ, Reardon C, Sherman PM, Barrett KE, Gareau MG. Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15;307(8):G793-802. doi: 10.1152/ajpgi.00238.2014. Epub 2014 Sep 4. PubMed PMID: 25190473; PubMed Central PMCID: PMC4200314.

Immunopathology

Brenner D, Brüstle A, Lin GH, Lang PA, Duncan GS, Knobbe-Thomsen CB, St Paul M, Reardon C, Tusche MW, Snow B, Hamilton SR, Pfefferle A, Gilani SO, Ohashi PS, Lang KS, Mak TW. Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1060-5. doi: 10.1073/pnas.1323166111. Epub 2014 Jan 7. PubMed PMID: 24398517; PubMed Central PMCID: PMC3903229.

Brüstle A, Brenner D, Knobbe CB, Lang PA, Virtanen C, Hershenfield BM, Reardon C, Lacher SM, Ruland J, Ohashi PS, Mak TW. The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells. J Clin Invest. 2012 Dec;122(12):4698-709. doi: 10.1172/JCI63528. Epub 2012 Nov 1. PubMed PMID: 23114599; PubMed Central PMCID: PMC3590210.

Magalhaes JG, Rubino SJ, Travassos LH, Le Bourhis L, Duan W, Sellge G, Geddes K, Reardon C, Lechmann M, Carneiro LA, Selvanantham T, Fritz JH, Taylor BC, Artis D, Mak TW, Comeau MR, Croft M, Girardin SE, Philpott DJ. Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci U S A. 2011 Sep6;108(36):14896-901. doi: 10.1073/pnas.1015063108.

Reardon C, Lechmann M, Brüstle A, Gareau MG, Shuman N, Philpott D, Ziegler SF, Mak TW. Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity. 2011 Aug 26;35(2):223-35. doi: 10.1016/j.immuni.2011.05.015. Epub 2011 Aug 4. PubMed PMID: 21820333; PubMed Central PMCID: PMC3169330.

Reardon C, Mak TW. cIAP proteins: keystones in NOD receptor signal transduction. Immunity. 2009 Jun 19;30(6):755-6. doi: 10.1016/j.immuni.2009.06.005. PubMed PMID: 19538923.

Reardon C, Wang A, McKay DM. Transient local depletion of Foxp3+ regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death. J Immunol. 2008 Jun 15;180(12):8316-26. PubMed PMID: 18523298.

Reardon C, McKay DM. TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages. J Immunol. 2007 Apr 1;178(7):4284-95. PubMed PMID: 17371985.

Persaud R, Wang A, Reardon C, McKay DM. Characterization of the immuno-regulatory response to the tapeworm Hymenolepis diminuta in the non-permissive mouse host. Int J Parasitol. 2007 Mar;37(3-4):393-403. Epub 2006 Oct 25. PubMed PMID: 17092505.

Howe KL, Reardon C, Wang A, Nazli A, McKay DM. Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability. Am J Pathol. 2005 Dec;167(6):1587-97. PubMed PMID: 16314472; PubMed Central PMCID: PMC1613202.

Reardon C, Sanchez A, Hogaboam CM, McKay DM. Tapeworm infection reduces epithelial ion transport abnormalities in murine dextran sulfate sodium-induced colitis. Infect Immun. 2001 Jul;69(7):4417-23. PubMed PMID: 11401981; PubMed
Central PMCID: PMC98514.

STED Super-resolution imaging

Nguyen TT, Kläsener K, Zürn C, Castillo PA, Brust-Mascher I, Imai DM, Bevins CL, Reardon C, Reth M, Baumgarth N. The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR. Nat Immunol. 2017 Mar;18(3):321-333. doi: 10.1038/ni.3677. Epub 2017 Jan 30. PubMed PMID: 28135254; PubMed Central PMCID: PMC5310993.

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